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Idiopathic inflammatory bowel disease consists of Crohn's disease and ulcerative colitis.
Crohn's disease can affect any part of the gastrointestinal tract, from the mouth to the anus, and is known as regional enteritis, terminal ileitis, or granulomatous colitis. Ulcerative colitis is limited to the colon and rectal involvement is present 95% of the time. It has long been known that the development of Crohn's disease somehow involves infection with Mycobacterium paratuberculosis, a relative of the bacterium that causes tuberculosis. Researchers originally believed that it was the primary cause of the disease, but now recognize that there are autoimmune manifestations associated with the disease and know that disease development is much more complicated than originally believed.
There are many different levels of disease manifestation, but most people with the disease experience gastrointestinal distress due to bowel inflammation, persistent diarrhea and wasting associated with diminished nutritional uptake. These individuals are also much more susceptible than normal to enteric (gut) infections.
Routine utilization of very high quality bovine colostrum, such as that distributed by Immune-Tree, would be very advantageous to affected individuals for a number of reasons.
1. Insulin-like growth factor-1 (IGF-1) is a hormone-like substance found in colostrum. IGF-1 is the triggering substance for a whole superfamily of 87 proteins that control most of the processes in every cell in the body. One of the major functions is regulation of the metabolic pathway by which the body converts glucose (sugar) to glycogen. Glycogen is stored in the muscles and the liver and is the main source of energy when the muscles are exercised. Another major function of IGF-1 and the superfamily is regulating how cells use amino acids to build proteins. Having sufficient IGF-1 available is extremely important in metabolically compromised individuals and is essential to reversing the wasting aspects of the disease.
2. Another function of the IGF superfamily is the repair of damaged cells. Most of the proteins in the superfamily are present in almost every cell in the body, but require activation and direction by the attachment of IGF-1 to specific sites on a cell's surface. Again, having sufficient IGF-1 available is critical to affect cell repair.
3. Colostrum also contains a number of gut protective factors that can act in concert to control enteric infections. Some of the most important ones are:
a) The IgA immunoglobulins directed against various bacteria and viruses, like E. coli, Staph. aureus, etc., that can attack the gut and, more particularly, weakened tissue. IgA will not only attach itself to a microorganism, but can also attach itself to tissue and immobilize the invading agent, letting other factors act to destroy it.
b) Lactoferrin and transferrin are iron-binding proteins. Certain bacteria and some viruses that invade the gut require iron to reproduce and, when this substance is withheld, they will die.
c) Lysozyme and lactoperoxidase are powerful enzymes that can attach to bacteria and eat holes through their outer wall.
4. One of the problems is making sure that a substantial portion of these biologically active substances gets through the stomach and into the intestines where they are needed. This is accomplished by using complete first milking colostrum that contains all of the fat and casein, like the colostrum products distributed by Immune-Tree. Although some manufacturers say that the fat and casein have no role in colostrum, that is utter nonsense. The human stomach contains an enzyme, rennin, that is also found in bovines and other species. Rennin acts on the fat and casein in dairy products to form a soft cheese-like curd that protects the biologically active substances against the enzymes and acid environment of the stomach, allowing the substances to either pass through within the curd as it disintegrates and/or to be absorbed into the circulation.
To your good health - always.
Sincerely,
Alfred E. Fox, Ph.D.
Dr. Alfred E. Fox holds a Ph.D. from Rutgers University in Microbiology (Immunochemistry) and has more than 25 years of senior management experience at Carter-Wallace, Baxter Dade Division and Warner-Lambert, where he was responsible for research and development and regulatory affairs. He was also the founder and president of two biotechnology companies focused on agribusiness and environmental monitoring, respectively. For the past 15 years, Dr. Fox has been the President of Fox Associates, a business and technology consulting firm serving small- to mid-size companies in the human and animal healthcare fields. He focuses primarily on marketing and regulatory issues and for the past 10 years has continuously consulted to bovine colostrum manufacturers, where he has gained regulatory approval for their products, been a technical advisor, helped design and develop marketing strategies and served as an expert witness in legal matters.
Crohn's disease can affect any part of the gastrointestinal tract, from the mouth to the anus, and is known as regional enteritis, terminal ileitis, or granulomatous colitis. Ulcerative colitis is limited to the colon and rectal involvement is present 95% of the time. It has long been known that the development of Crohn's disease somehow involves infection with Mycobacterium paratuberculosis, a relative of the bacterium that causes tuberculosis. Researchers originally believed that it was the primary cause of the disease, but now recognize that there are autoimmune manifestations associated with the disease and know that disease development is much more complicated than originally believed.
There are many different levels of disease manifestation, but most people with the disease experience gastrointestinal distress due to bowel inflammation, persistent diarrhea and wasting associated with diminished nutritional uptake. These individuals are also much more susceptible than normal to enteric (gut) infections.
Routine utilization of very high quality bovine colostrum, such as that distributed by Immune-Tree, would be very advantageous to affected individuals for a number of reasons.
1. Insulin-like growth factor-1 (IGF-1) is a hormone-like substance found in colostrum. IGF-1 is the triggering substance for a whole superfamily of 87 proteins that control most of the processes in every cell in the body. One of the major functions is regulation of the metabolic pathway by which the body converts glucose (sugar) to glycogen. Glycogen is stored in the muscles and the liver and is the main source of energy when the muscles are exercised. Another major function of IGF-1 and the superfamily is regulating how cells use amino acids to build proteins. Having sufficient IGF-1 available is extremely important in metabolically compromised individuals and is essential to reversing the wasting aspects of the disease.
2. Another function of the IGF superfamily is the repair of damaged cells. Most of the proteins in the superfamily are present in almost every cell in the body, but require activation and direction by the attachment of IGF-1 to specific sites on a cell's surface. Again, having sufficient IGF-1 available is critical to affect cell repair.
3. Colostrum also contains a number of gut protective factors that can act in concert to control enteric infections. Some of the most important ones are:
a) The IgA immunoglobulins directed against various bacteria and viruses, like E. coli, Staph. aureus, etc., that can attack the gut and, more particularly, weakened tissue. IgA will not only attach itself to a microorganism, but can also attach itself to tissue and immobilize the invading agent, letting other factors act to destroy it.
b) Lactoferrin and transferrin are iron-binding proteins. Certain bacteria and some viruses that invade the gut require iron to reproduce and, when this substance is withheld, they will die.
c) Lysozyme and lactoperoxidase are powerful enzymes that can attach to bacteria and eat holes through their outer wall.
4. One of the problems is making sure that a substantial portion of these biologically active substances gets through the stomach and into the intestines where they are needed. This is accomplished by using complete first milking colostrum that contains all of the fat and casein, like the colostrum products distributed by Immune-Tree. Although some manufacturers say that the fat and casein have no role in colostrum, that is utter nonsense. The human stomach contains an enzyme, rennin, that is also found in bovines and other species. Rennin acts on the fat and casein in dairy products to form a soft cheese-like curd that protects the biologically active substances against the enzymes and acid environment of the stomach, allowing the substances to either pass through within the curd as it disintegrates and/or to be absorbed into the circulation.
To your good health - always.
Sincerely,
Alfred E. Fox, Ph.D.
Dr. Alfred E. Fox holds a Ph.D. from Rutgers University in Microbiology (Immunochemistry) and has more than 25 years of senior management experience at Carter-Wallace, Baxter Dade Division and Warner-Lambert, where he was responsible for research and development and regulatory affairs. He was also the founder and president of two biotechnology companies focused on agribusiness and environmental monitoring, respectively. For the past 15 years, Dr. Fox has been the President of Fox Associates, a business and technology consulting firm serving small- to mid-size companies in the human and animal healthcare fields. He focuses primarily on marketing and regulatory issues and for the past 10 years has continuously consulted to bovine colostrum manufacturers, where he has gained regulatory approval for their products, been a technical advisor, helped design and develop marketing strategies and served as an expert witness in legal matters.
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Colostrum heals the gastrointestinal tract, as it has skin growth hormones in it. Today, way too many people
have gastrointestinal permeability problems, which can lead not only to digestive issues like colitis, diverticulitis, or leaky
gut syndrome, but also allergies and conditions like diabetes. There are no other substances on earth that can heal
gastrointestinal permeability like colostrum can. Therefore, it should be added to the leaky gut syndrome diet or
supplement regime for gastrointestinal ailments.
The colostrum will also remove diseased bacteria from the gut. It keeps viruses from entering our cells in the first place. There are actually a long list of diseases that colostrum has shown to heal. Further, it has even been shown to build up lean muscle mass as well. As a result, many world-class athletes take colostrum supplements.
Once you start thinking about colostrum, it is clear that it is the most important food in the world. It is also the most complete food on earth. After all, it is the first food that most people have been given. You can rebuild your digestive system rapidly and effectively when you take colostrum and probiotics together.
Taken from: http://holisticgastroenterology.com/category/leaky-gut-syndrome
The colostrum will also remove diseased bacteria from the gut. It keeps viruses from entering our cells in the first place. There are actually a long list of diseases that colostrum has shown to heal. Further, it has even been shown to build up lean muscle mass as well. As a result, many world-class athletes take colostrum supplements.
Once you start thinking about colostrum, it is clear that it is the most important food in the world. It is also the most complete food on earth. After all, it is the first food that most people have been given. You can rebuild your digestive system rapidly and effectively when you take colostrum and probiotics together.
Taken from: http://holisticgastroenterology.com/category/leaky-gut-syndrome
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Co-administration of the health food supplement, bovine colostrum, reduces the acute
non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.
Clin Sci. 2001.
Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal injury. Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice. We therefore examined whether spray-dried, colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons.
Healthy male volunteers (n=7) participated in a randomized crossover trial comparing changes in gut permeability (lactulose/rhamnose ratios) before and after 5 days of 50 mg of indomethacin three times daily (tds) per oral with colostrum (125 ml, tds) or whey protein (control) co-administration. A second study examined the effect of colostral and control solutions (125 ml, tds for 7 days) on gut permeability in patients (n=15) taking a substantial, regular dose of an NSAID for clinical reasons. For both studies, there was a 2 week washout period between treatment arms. In volunteers, indomethacin caused a 3-fold increase in gut permeability in the control arm (lactulose/rhamnose ratio 0.36+/-0.07 prior to indomethacin and 1.17+/-0.25 on day 5, P<0.01), whereas no significant increase in permeability was seen when colostrum was co-administered. In patients taking long-term NSAID treatment, initial permeability ratios were low (0.13+/-0.02), despite continuing on the drug, and permeability was not influenced by co-administration of test solutions. These studies provide preliminary evidence that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans.
Clin Sci. 2001.
Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal injury. Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice. We therefore examined whether spray-dried, colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons.
Healthy male volunteers (n=7) participated in a randomized crossover trial comparing changes in gut permeability (lactulose/rhamnose ratios) before and after 5 days of 50 mg of indomethacin three times daily (tds) per oral with colostrum (125 ml, tds) or whey protein (control) co-administration. A second study examined the effect of colostral and control solutions (125 ml, tds for 7 days) on gut permeability in patients (n=15) taking a substantial, regular dose of an NSAID for clinical reasons. For both studies, there was a 2 week washout period between treatment arms. In volunteers, indomethacin caused a 3-fold increase in gut permeability in the control arm (lactulose/rhamnose ratio 0.36+/-0.07 prior to indomethacin and 1.17+/-0.25 on day 5, P<0.01), whereas no significant increase in permeability was seen when colostrum was co-administered. In patients taking long-term NSAID treatment, initial permeability ratios were low (0.13+/-0.02), despite continuing on the drug, and permeability was not influenced by co-administration of test solutions. These studies provide preliminary evidence that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans.
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by Dr. Alfred E. Fox
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As colostrum becomes a more popular
treatment for intestinal permeability (leaky gut
syndrome) and irritable bowel syndrome (IBS),
information about the supplement's immune
factors and benefits have become more
widespread. Donald Henderson, M.D., M.P.H., a
gastroenterologist and chief of staff at Daniel
Freeman Memorial Hospital in Los Angeles, is
one who recommends colostrum as a digestive
treatment. "Colostrum has the greatest
components of ingredients directed toward
the digestive tract," said Henderson. "Its
growth factors help cells of the digestive
tract redevelop themselves and it also has
immune factors that reestablish the
immunity of the gastrointestinal tract and
kill off bad bacteria that is overgrown."
Colostrum decreases intestinal permeability and
enhances the assimilation of nutrients.
After years of research, doctors have found that bovine colostrum provides similar immune factors as human colostrum. In fact, bovine colostrum may be up to 40 times richer in immune factors, depending on its source and how it is processed.Immunoglobulins, lactoferrin, cytokines and interferon are powerful immune factors found in colostrum and are key to the supplement's effectiveness. Immunoglobulins are large protein molecules that comprise more than 40 percent of proteins and are found in the body's blood serum. There are five classes of immunoglobulins--each with its own amino acid structure and function in the body. These molecules can attach to, penetrate, destroy or immobilize specific antigens. Colostrum contains all five of these molecules and polyproline-rich-pepetides, which have been proven to boost an underactive immune system.A recent study determined that bovine immunoglobulins concentrate (BIC)-Clostridium difficile could pass through the human stomach and small intestine. The study also found that since BIC-C difficile could resist digestion in the human upper gastrointestinal tract, it could be a useful non-antibiotic approach to the prevention and treatment of diarrhea and colitis. (Gut 1999 Feb; 44(2): 212-7).
Since colostrum can decrease Leaky Gut Syndrome i.e. intestinal permeability and enhance the assimilation of nutrients, using colostrum as a foundation supplement can enhance the bioavailability of nutrients and protect the digestive tract from toxins and pathogenic invaders. This effect can also be increased when combined with probiotics.
After years of research, doctors have found that bovine colostrum provides similar immune factors as human colostrum. In fact, bovine colostrum may be up to 40 times richer in immune factors, depending on its source and how it is processed.Immunoglobulins, lactoferrin, cytokines and interferon are powerful immune factors found in colostrum and are key to the supplement's effectiveness. Immunoglobulins are large protein molecules that comprise more than 40 percent of proteins and are found in the body's blood serum. There are five classes of immunoglobulins--each with its own amino acid structure and function in the body. These molecules can attach to, penetrate, destroy or immobilize specific antigens. Colostrum contains all five of these molecules and polyproline-rich-pepetides, which have been proven to boost an underactive immune system.A recent study determined that bovine immunoglobulins concentrate (BIC)-Clostridium difficile could pass through the human stomach and small intestine. The study also found that since BIC-C difficile could resist digestion in the human upper gastrointestinal tract, it could be a useful non-antibiotic approach to the prevention and treatment of diarrhea and colitis. (Gut 1999 Feb; 44(2): 212-7).
Since colostrum can decrease Leaky Gut Syndrome i.e. intestinal permeability and enhance the assimilation of nutrients, using colostrum as a foundation supplement can enhance the bioavailability of nutrients and protect the digestive tract from toxins and pathogenic invaders. This effect can also be increased when combined with probiotics.